Here are the sites I've got the opportunity to work on, each with its own unique layout, graphics, structure, color scheme, and many other design properties.
Unlike most platforms, Webflow gives complete control over the website design customization down to every pixel, and requires more technical work. You can customize a website without hitting design limitations. It has superior design functionality compared to Shopify, but the third-party apps will have to be integrated manually.
A great eCommerce platform if you don't have technical skills, and want something that is simple to use and unlike Webflow it integrates third-party apps automatically into the platform. Shopify has a great selection of themes, but if you want a custom design, you're going to be limited by the fixed structure of themes.